To tie the knot significa amarrar o nó literalmente. Por ser uma expressão idiomática, significa casar-se em inglês.

She wouldn't be that silly as to tie the knot with him.

She wouldn't be that silly as to tie the knot with him.
(Ela não seria tão idiota de casar com ele.)
Maybe he has good reasons for not feeling ready to tie the knot yet.
Maybe he has good reasons for not feeling ready to tie the knot yet.
(Talvez ele tenha boas razaões para não se sentir pronto para casar-se ainda.)